Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

Contemporary preclinical models suggest that abnormal functioning of a brain network consisting the hippocampus, midbrain and striatum plays critical role in pathophysiology schizophrenia. Previous neuroimaging studies examined individual aspects this model schizophrenia patients individuals at clinical high risk for psychosis. However, exact has not been translated to human with therefore it is currently unknown how altered patients. Here we investigated resting state functional connectivity hippocampus-midbrain-striatum patients, using Magnetic Resonance Imaging. Based on models, functionally validated regions comprising anterior subiculum (SUB), limbic (LS), ventral tegmental area (VTA) associative (AS) was 47 51 healthy controls. Schizophrenia demonstrated significantly lower compared controls (p = 0.036). Particular reductions were found between SUB LS (0.002 ± 0.315 0.116 0.224, p 0.040) VTA AS (0.230 0.268 0.356 0.285, 0.026). In associated positive, negative or general symptom scores. Reduced consistent concept dysconnectivity as key feature disorder. Our results support notion